Malaria case-management under artemether-lumefantrine treatment policy in Uganda.


Background: Case-management with artemether-lumefantrine (AL) is one of the key strategies to control malaria in many African countries. Yet, the reports on translation of AL implementation activities into clinical practice are scarce. Here the quality of AL case-management is reported from Uganda, approximately one year after AL replaced the combination of chloroquine and sulphadoxine-pyrimethamine (CQ+SP) as recommended first line treatment for uncomplicated malaria. Methods: A cross-sectional survey, using a range of quality of care assessment tools, was undertaken at all government and private-not-for-profit facilities in four Ugandan districts. Main outcome measures were AL prescribing, dispensing and counseling practices in comparison with national guidelines, and factors influencing health workers' decision to 1) treat for malaria, and 2) prescribe AL. Results: 195 facilities, 232 health workers and 1763 outpatient consultations were evaluated. Among 1200 patients who needed treatment with AL according to guidelines, AL was prescribed for 60%, CQ+SP for 14%, quinine for 4%, CQ for 3%, other antimalarials for 3%, and no antimalarial drug for 16%. AL was prescribed in the correct dose for 95% of patients. Only three out of seven AL counseling and dispensing tasks were performed for more than 50% of patients. Patients were more likely to be treated for malaria if they presented with a main complaint of fever (OR = 5.22; 95% CI: 3.61–7.54) and if they were seen by supervised health workers (OR = 1.63; 95% CI: 1.06–2.50); they were less likely to be so treated by more qualified health workers (OR = 0.61; 95% CI: 0.40–0.93) or if they presented with skin problems (OR = 0.29; 95% CI: 0.15–0.55). AL was more likely to be prescribed if the appropriate weight-specific AL pack was in stock (OR = 6.15; 95% CI: 3.43–11.05) and when CQ was absent (OR = 2.16; 95% CI: 1.09–4.28). Routine AL implementation activities were not associated with better performance. Conclusion: Although the use of AL was predominant over non-recommended therapies, the quality of AL case-management at the point of care is not yet optimal. There is an urgent need for innovative quality improvement interventions, which should be rigorously tested. Adequate availability of ACTs at the point of care will, however, ultimately determine the success of any performance interventions and ACT policy transitions.


Malaria Journal (2008) 7:181 [doi:10.1186/1475-2875-7-181].

Malaria case-management under artemether-lumefantrine treatment policy in Uganda.

Published 1 January 2008