Key issues in TB drug research and development are explored in this issue, which contains articles commissioned and edited by the TB Alliance. The articles explore key aspects and challenges in each phase of the TB drug research and development process. Within discovery research, this includes target discovery and validation, identification of new targets, lead optimization, and choice of animal models. Clinical topics include discussions of the pharmacokinetics and pharmacodynamics of TB drug candidates, the role(s) of Early Bactericidal Activity studies, the design of pivotal TB drug trials, and a regulatory perspective on developing new drugs for multidrug-resistant TB (MDR-TB).
Tuberculosis (2008) 88, Supplement 1, 1-100