What is strongyloides infection and how might ivermectin work
Strongyloides stercoralis is a parasite that lives in the gut of
infected people. The infection is not serious for most people, but it
can be fatal in people with immune deficiency. People become infected
when they come in contact with soil or water contaminated with
infectious worms. The chronic infection usually causes skin rash,
vomiting, diarrhoea, and constipation, and respiratory problems, such as
asthma-like illness. This disease may be treated with ivermectin or
albendazole or thiabendazole. We wanted to know if ivermectin was better
or worse than the other alternative therapies.
What the research says
We reviewed the evidence about the effect of ivermectin compared with
albendazole and thiabendazole. After searching for relevant trials up to
August 2015, we included seven randomized controlled trials, enrolling
1147 adults with chronic strongyloides infection, conducted between 1994
and 2011 in different locations (Africa, Southeast Asia, America, and
Europe). Four trials assessed the effectiveness of ivermectin compared
with albendazole and three trials assessed the effectiveness of
ivermectin compared with thiabendazole.
Comparison ivermectin versus albendazole
Treatment with ivermectin probably cures more people than albendazole
(moderate quality evidence), and may be equally or better tolerated (low
quality evidence). The included trials did not report serious adverse
events or death.
Comparison ivermectin versus thiabendazole
Treatment with ivermectin and thiabendazole may cure similar numbers of
people with strongyloides infection (low quality evidence), but
ivermectin is probably better tolerated (moderate quality evidence). The
included trials did not report serious adverse events or death.
Henriquez-Camacho, C.; Gotuzzo, E.; Echevarria, J.; White Jr., A.C.; Terashima, A.; Samalvides, F.; Pérez-Molina, J.A.; Plana, M.N. Ivermectin versus albendazole or thiabendazole forStrongyloides stercoralisinfection. Cochrane Database of Systematic Reviews (2016) Issue 1, Art. No.: CD007745. [DOI: 10.1002/14651858.CD007745.pub3]
Ivermectin versus benzimidazoles for treating Strongyloides stercoralis infection