Two small trials that compared arteether with intravenous quinine in 194 children were reviewed but the data were too limited to determine the effects of arteether on death, neurological complications at follow up, time to regain consciousness, parasite clearance time, presence of parasites on days 7 and 28, fever clearance time, and adverse events. It is concluded that there is insufficient research to know whether arteether is better or worse than quinine for patients with severe malaria.
This Evidence Update was adapted from Afolabi BB, Okoromah CN. Intramuscular arteether for treating severe malaria. The Cochrane Database of Systematic Reviews 2004, Issue 4. Art. No.: CD004391. DOI: 10.1002/14651858.CD004391.pub2.
Malaria Series, Effective Health Care Alliance Programme, Liverpool School of Tropical Medicine, 2 pp.
Is intramuscular arteether (also known as artemotil) as effective as other antimalarial drugs in people with severe malaria? Evidence Update, Malaria Series, January 2005