This project focused on optimising the in vitro culture system for Cowdria ruminantium, characterising Cowdria in tick cells at the morphological, antigenic and molecular levels, and testing its infectivity and immunogenicity in sheep. The project demonstrated that Cowdria grown in tick cell lines offers an alternative and complementary source of antigens and effective immunogens which will contribute to improved immunisation and diagnosis of heartwater.
DFID Animal Health Programme, Final Technical Report, project R7363. Centre for Tropical Veterinary Medicine, University of Edinburgh. 23 pp.
Investigation of the immunogenic potential of heartwater (Cowdria ruminantium) grown in tick cell lines. Final Technical Report, project R7363.