Schistosoma mansoni is a parasite that infects the intestine, liver and spleen and can be fatal. People become infected when they come in contact with contaminated water. The review found that the drugs oxamniquine and praziquantel are both effective for curing the infection. Evidence from one trial shows that zinc supplements do not help to prevent re-infection. A small number of patients given oxamniquine have suffered seizures which could mean that this drug is less safe.
The Cochrane Database of Systematic Reviews 1999, Issue 3. Art. No.: CD000528. DOI: 10.1002/14651858.CD000528.