In areas of endemic transmission, malaria in pregnancy is associated with severe maternal anaemia and low-birthweight babies. The authors studied the efficacy of intermittent treatment doses of sulphadoxine-pyrimethamine in preventing malaria and severe anaemia in pregnancy in a double-blind placebo-controlled trial among primigravid women living in Kilifi District, Kenya.
Shulman, C.E.; Dorman, E.K.; Cutts, F.;Kawuondo, K.; Bulmer, J.N.; Peshu,N.; Marsh, K. Intermittent sulphadoxine-pyrimethamine to prevent severe anaemia secondary to malaria in pregnancy: a randomised placebo-controlled trial. Lancet (1999) 353 (9153) 632-636. [DOI: 10.1016/S0140-6736(98)07318-8]