Intermittent preventive antimalarial treatment for children with anaemia

This review examines 6 trials, in which one group received IPT and the control group received placebo


Children living in malaria areas may develop severe anaemia, often caused by malaria infection, and this can cause death if not treated properly. Intermittent preventive treatment (IPT) is a course of malaria treatment given regularly to these children in order to prevent infection and malaria illness. It has been suggested that IPT could be used to treat children with anaemia in these areas. We aimed to find all the studies looking at treating anaemic children with IPT in order to see what the overall effect is. We examined the evidence available up to 4 December 2014.

We included 6 trials in this review, with a total number of 3847 participants. In all the trials, one group received IPT and the control group received placebo. 3 trials were done in low malaria endemicity areas and the other 3 in high endemicity areas. In some trials, iron supplements were also given to children, which is also a treatment for anaemia, and we took this into consideration when analysing the data.

Our results did not find that the number of children who died or were admitted to hospital was lower in the group receiving IPT, irrespective of whether they received iron (moderate quality evidence); and there was no difference in the number of children with anaemia at the end of follow-up (moderate quality evidence). Average haemoglobin levels were higher in the IPT group compared to the placebo group, but the effect was modest (low quality evidence).

Although our results show that there are small benefits in haemoglobin levels when treating anaemic children with IPT, we did not detect an effect on death or hospital admissions. However, 3 of the 6 included trials were conducted in low endemicity areas where malaria transmission is low and thus any protective effect is likely to be modest.

This research is supported by the Department for International Development’s Evidence Building and Synthesis Research Programme which is led by Liverpool School of Tropical Medicine


Athuman, M.; Kabanywanyi, A.M.; Rohwer, A.C. Intermittent preventive antimalarial treatment for children with anaemia. Cochrane Database of Systematic Reviews (2015) Issue 1, Art. No.: CD010767. [DOI: 10.1002/14651858.CD010767.pub2]

Intermittent preventive antimalarial treatment for children with anaemia

Published 13 January 2015