Increase in CD5+ B cells and depression of immune responses in sheep infected with Trypanosoma evansi

Abstract

The effects of Trypanosoma evansi on the cellular and humoral immune responses of sheep to Pasteurella haemolytica vaccine were studied. Peripheral blood lymphocytes (PBLs) from the sheep were analysed using single and double-colour indirect immunofluorescence staining and flow cytometry to monitor changes in circulating B and T cell subsets. Serum antibody responses were assayed using the enzyme-linked immunosorbent assay technique (ELISA), in addition to measuring local skin reactions at the site of vaccine administration. Results showed significant increases in circulating B cells in all sheep after the primary (p

Citation

Onah, D.N.; Hopkins, J.; Luckins, A.G. Increase in CD5+ B cells and depression of immune responses in sheep infected with Trypanosoma evansi. Veterinary Immunology and Immunopathology (1998) 63 (3) 209-222. [DOI: 10.1016/S0165-2427(97)00147-5]

Increase in CD5+ B cells and depression of immune responses in sheep infected with Trypanosoma evansi

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