Human Herpesvirus-8 Infection and Oral Shedding in Amerindian and Non-Amerindian Populations in the Brazilian Amazon Region

Abstract

Background. Human herpesvirus type 8 (HHV-8) is hyperendemic in Amerindian populations, but its modes of transmission are unknown. Methods. Antibodies against either HHV-8 lytic antigen or HHV-8 latency-associated nuclear antigen (LANA) were detected, by immunofluorescence assays, in 339 Amerindians and 181 non-Amerindians from the Brazilian Amazon. Serological markers of oro-fecal (hepatitis A), parenteral (hepatitis B and C), and sexual (herpes simplex virus type 2 and syphilis) transmission were measured by specific ELISAs. Salivary HHV-8 DNA was detected by use of a nested polymerase chain reaction assay and was sequenced. Results. Antibodies against either lytic antigen or LANA were detected in 79.1% of Amerindians and in 6.1% of non-Amerindians (adjusted seroprevalence ratio [SR], 12.63 [95% confidence interval {CI}, 7.1-22.4]; P

Citation

Journal of Infectious Diseases (2007) 196 (6) pp. 844-852 [DOI:10.1086/520549].

Human Herpesvirus-8 Infection and Oral Shedding in Amerindian and Non-Amerindian Populations in the Brazilian Amazon Region

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