The objective of this review was to quantify the effect of first-line antihypertensive treatment with beta-blockers on mortality, morbidity and withdrawal rates, compared with the other main classes of antihypertensive agents.
Bradley, H.; Wiysonge, C.; Volmink, J.; Mayosi, B.; Opie, L. How strong is the evidence for use of beta-blockers as first-line therapy for hypertension? Systematic review and meta-analysis. Journal of Hypertension (2006) 24 (11) 2131-214. [DOI: 10.1097/01.hjh.0000249685.58370.28]