Results from 56 randomized and quasi-randomized controlled trials conducted during and after 1980, mostly in Africa, support the continued use of amodiaquine to treat uncomplicated malaria, although local drug resistance patterns need to be considered and monitoring for adverse events should continue.
This Evidence Update was adapted from Olliaro P, Mussano P. Amodiaquine for treating malaria (Cochrane Review). In: The Cochrane Library, Issue 4, 2003.
Malaria Series, Effective Health Care Alliance Programme, Liverpool School of Tropical Medicine, 2 pp.
How safe and effective is amodiaquine compared to chloroquine or sulfadoxine-pyrimethamine for treating uncomplicated malaria? Evidence Update, Malaria Series, November 2003