High Circulating Frequencies of Tumor Necrosis Factor Alpha- and Interleukin-2-Secreting Human T-Lymphotropic Virus Type 1 (HTLV-1)-Specific CD4+ T Cells in Patients with HTLV-1-Associated Neurological Disease

• From: Department for International Development
• Published: 1 January 2003

• Document Type: Journal Article
• Theme: Health
• Authors: Weber, J.N., Bangham, C.R.M., Goon, P.K.C., Hanon, E., Igakura, T., Mosley, A.J., Taylor, G.P., Asquith, B., Gould, K.G.

Abstract

Significantly higher frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4+ T cells were present in the peripheral blood mononuclear cells of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients than in those of asymptomatic carriers with similar provirus loads. The data suggest that HTLV-1-specific CD4+ T cells play a role in the pathogenesis of HAM/TSP.

Citation

Goon, P.K.C.; Igakura, T.; Hanon, E.; Mosley, A.J.; Asquith, B.; Gould, K.G.; Taylor, G.P.; Weber, J.N.; Bangham, C.R.M. High Circulating Frequencies of Tumor Necrosis Factor Alpha- and Interleukin-2-Secreting Human T-Lymphotropic Virus Type 1 (HTLV-1)-Specific CD4+ T Cells in Patients with HTLV-1-Associated Neurological Disease. Journal of Virology (2003) 77 (17) 9716-9722. [DOI: 10.1128/?JVI.77.17.9716-9722.2003]

Links

High Circulating Frequencies of Tumor Necrosis Factor Alpha- and Interleukin-2-Secreting Human T-Lymphotropic Virus Type 1 (HTLV-1)-Specific CD4+ T Cells in Patients with HTLV-1-Associated Neurological Disease

Published 1 January 2003