Cassava is a crucial, under-researched crop feeding millions worldwide, especially in Africa. Cassava mosaic disease (CMD) has plagued production in Africa for over a century. Biparental mapping studies suggest primarily a single major gene mediates resistance. To investigate this genetic architecture, the authors conducted the first genome-wide association mapping study in cassava with up to 6128 genotyping-by-sequenced African breeding lines and 42,113 reference genome-mapped single-nucleotide polymorphism (SNP) markers.
This work is part of the “Next Generation Cassava Breeding Project” which is supported by the UK Department for International Development, in partnership with the Bill & Melinda Gates Foundation.
Wolfe, M. D., I. Y. Rabbi, C. Egesi, M. Hamblin, R. Kawuki, P. Kulakow, R. Lozano, D. P. D. Carpio, P. Ramu, and J. Jannink. 2016. Genome-Wide Association and Prediction Reveals Genetic Architecture of Cassava Mosaic Disease Resistance and Prospects for Rapid Genetic Improvement. Plant Genome 9. doi:10.3835/plantgenome2015.11.0118
Genome-Wide Association and Prediction Reveals Genetic Architecture of Cassava Mosaic Disease Resistance and Prospects for Rapid Genetic Improvement