Genome-Wide Association and Prediction Reveals Genetic Architecture of Cassava Mosaic Disease Resistance and Prospects for Rapid Genetic Improvement
Cassava mosaic disease (CMD) has plagued production in Africa for over a century
Abstract
Cassava is a crucial, under-researched crop feeding millions worldwide, especially in Africa. Cassava mosaic disease (CMD) has plagued production in Africa for over a century. Biparental mapping studies suggest primarily a single major gene mediates resistance. To investigate this genetic architecture, the authors conducted the first genome-wide association mapping study in cassava with up to 6128 genotyping-by-sequenced African breeding lines and 42,113 reference genome-mapped single-nucleotide polymorphism (SNP) markers.
This work is part of the “Next Generation Cassava Breeding Project” which is supported by the UK Department for International Development, in partnership with the Bill & Melinda Gates Foundation.
Citation
Wolfe, M. D., I. Y. Rabbi, C. Egesi, M. Hamblin, R. Kawuki, P. Kulakow, R. Lozano, D. P. D. Carpio, P. Ramu, and J. Jannink. 2016. Genome-Wide Association and Prediction Reveals Genetic Architecture of Cassava Mosaic Disease Resistance and Prospects for Rapid Genetic Improvement. Plant Genome 9. doi:10.3835/plantgenome2015.11.0118