Not enough sound evidence for using fluoroquinolones in typhoid and paratyphoid fever compared with the standard antibiotics. The potentially fatal typhoid and paratyphoid fevers are caused by bacterial infection that begins in the small intestine (enteric fever). Transmission occurs through contaminated food and water, and there are areas where these diseases are endemic, such as Asia, Africa, and South and Central America. People often relapse or become carriers. Chloramphenicol has been the standard treatment, but the bacteria are becoming resistant. A new group of drugs, the fluoroquinolones, are being tried, but the review of trials found there were insufficient numbers of participants in the trials to be able to give recommendations with any degree of certainty.
The Cochrane Database of Systematic Reviews 2005, Issue 2. Art. No.: CD004530. DOI: 10.1002/14651858.CD004530.pub2.