This report covers a multi-component project evaluating the technical issues concerning the use of ammonium-based ionic liquids as solvents for the extraction of artemisinin from Artemisia annua. The previously studied solvent N,N-dimethylethanolammonium octanoate was further evaluated for this application, with particular emphasis being placed on the elucidation of its extraction profile and the issues associated with the recovery of artemisinin from solution. Results from these studies were subsequently used to design an iteratively improved solvent, which was similarly evaluated in order to establish key design parameters for a solvent geared for optimal extraction performance. The results reported herein delineate a template for the development of a commercially viable ionic liquid to address these requirements.
Extraction of artemisinin using ionic liquids. Report by Bioniqs Limited, 15th February 2008; 27 pp.