Experimental models for lead optimisation of novel antileishmanial agents
After brief introducions to different in vitro and in vivo methods for testing the efficacy and safety of new antileishmanial agents, this presentation describes the luciferase assay using Leishmania parasites transfected with a luciferase gene so the presence of live parasites is indicated by the emission of light, and the use of the Golden Hamster as an experimentally infected animal. Examples of the use of these models for drug testing are given.
Presentation from ‘Challenges for and Potential in the Early-Stage R&D Pipeline to Develop New Antileishmanial Drugs. Symposium held at World Leish 4, Lucknow, India, 4 February 2009.