Experimental models for lead optimisation of novel antileishmanial agents

From:
Department for International Development
Published
1 January 2009
Document Type:
Conference Paper
Theme:
Health
Authors:
Puri, S.

Abstract

After brief introducions to different in vitro and in vivo methods for testing the efficacy and safety of new antileishmanial agents, this presentation describes the luciferase assay using Leishmania parasites transfected with a luciferase gene so the presence of live parasites is indicated by the emission of light, and the use of the Golden Hamster as an experimentally infected animal. Examples of the use of these models for drug testing are given.

Citation

Presentation from ‘Challenges for and Potential in the Early-Stage R&D Pipeline to Develop New Antileishmanial Drugs. Symposium held at World Leish 4, Lucknow, India, 4 February 2009.

Experimental models for lead optimisation of novel antileishmanial agents

Published 1 January 2009
Contents