- Department for International Development
- Document Type:
- Journal Article
- Donald, P.R., Diacon, A.H., Spigelman, M., van Niekerk, C., Dawson, R. Everitt, D., Mendel, C.M., Venter, A., von Groote-Bidlingmaier, F., Burger, D.A., Schall, R., Conradie, A., Eisenach, K., Ive, P., Ntinginya, N.E., Page-Shipp, L., Pym, A., Reigher, K., and Variava, E.
New antituberculosis regimens are urgently needed to shorten tuberculosis treatment. Following on from favourable assessment in a 2 week study, we investigated a novel regimen for efficacy and safety in drug-susceptible and multidrug-resistant (MDR) tuberculosis during the first 8 weeks of treatment. A combination of moxifloxacin, pretomanid, and pyrazinamide, was safe, well tolerated, and showed superior bactericidal activity in drug-susceptible tuberculosis during 8 weeks of treatment. Results were consistent between drug-susceptible and MDR tuberculosis. This new regimen is ready to enter phase 3 trials in patients with drug-susceptible tuberculosis and MDR-tuberculosis, with the goal of shortening and simplifying treatment.
Dawson, R.; Diacon, A.H.; Everitt, D.; van Niekerk, C.; Donald, P.R.; Burger, D.A.; Schall, R.; Spigelman, M.; Conradie, A.; Eisenach, K.; Venter, A.; Ive, P.; Page-Shipp, L.; Variava, E.; Reigher, K.; Ntinginya, N.E.; Pym, A.; von Groote-Bidlingmaier, F.; Mendel, C.M. Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase 2b, open-label, partly randomised trial in patients with drug-susceptible or drug-resistant pulmonary tuberculosis. Lancet (2015) 385 (9979) 1738-1747. [DOI: 10.1016/S0140-6736(14)62002-X]
Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase 2b, open-label, partly randomised trial in patients with drug-susceptible or drug-resistant pulmonary tuberculosis
Document Type: Journal Article
Authors: Donald, P.R. Diacon, A.H. Spigelman, M. van Niekerk, C. Dawson, R. Everitt, D. Mendel, C.M. Venter, A. von Groote-Bidlingmaier, F. Burger, D.A. Schall, R. Conradie, A. Eisenach, K. Ive, P. Ntinginya, N.E. Page-Shipp, L. Pym, A. Reigher, K. Variava, E.