The intradermal injection of Trypanosoma evansi or T. evansi components into rabbits evoked trypanosome-specific responses in the skin. The strongest responses, which were those against the parasite surface-associated components, had the characteristics of an immediate type hypersensitivity reaction, followed by a delayed type. The responses were greater in rabbits from which infections had been cleared by chemotherapy than in animals with patent infections. These findings suggest that variant surface glycoprotein, (VSG)-specific antibody activity and immunosuppression are effective in the skin and influence the outcome of infection with T. evansi in previously infected animals.
Uche, U.E.; Jones, T.W. Early events following challenge of rabbits with Trypanosoma evansi and T. evansi components. Journal of Comparative Pathology (1993) 109 (1) 1-11. [DOI: 10.1016/S0021-9975(08)80235-6]