Different influenza virus strains have caused a number of recent outbreaks killing scores of people and causing significant losses in animal farming. Simple, rapid, sensitive, and specific detection of particular strains, such as a pandemic strain versus a previous seasonal influenza, plays a crucial role in the monitoring, controlling, and management of outbreaks. In this paper we describe a dual recognition element lateral flow assay (DRELFA) which pairs a nucleic acid aptamer with an antibody for use as a point-of-care platform which can detect particular strains of interest.
This work arises from the Zoonoses and Emerging Livestock Systems (ZELS) programme.
Le T, Chang P, Benton D, McCauley J, Iqbal M, Cass A (2017). Dual Recognition Element Lateral Flow Assay Toward Multiplex Strain Specific Influenza Virus Detection. Analytical Chemistry 89(12): 6781-6786
Dual Recognition Element Lateral Flow Assay Toward Multiplex Strain Specific Influenza Virus Detection