DFID Zoonoses Report 6. Prioritising the need for new diagnostics, medicine, vaccines and management practices of zoonoses which have significant impact in the developing world.
The approach used for the study was based on a rapid appraisal of the literature and use of research tools, expert opinion and workshops to identify priorities for research into interventions for control of zoonoses in low and middle income countries (LMICs). The analysis was based on detailed studies of 20 zoonotic diseases, selected for their development relevance and to be representative of the diversity of zoonoses generally.
For each of 20 selected zoonoses, literature reviews and expert interviews were undertaken to identify opportunities for innovative technologies and management practices for control of zoonoses, focused primarily but not exclusively on Asia and Africa. Diagnostics, drugs, vaccines and management practices for each selected disease were considered.
Sections 1 and 2 of the report cover the study methodology and zoonotic disease selection. Section 3 considers the complex agricultural and health dimensions of zoonotic diseases and their impact in a development context. Then Section 4 considers the drivers which will influence the selection of interventions for research, including biological, socio-economic and cultural factors. A protocol is suggested for selecting interventions, based on these factors and its application to the 20 selected diseases is examined. Cross-cutting analyses drawing case studies from these diseases are examined identifying patterns of successful control, cross-cutting gaps and opportunities for research. In the following sections, we examine prioritization from the different perspective of interventions, considering diagnostics (Section 5), drugs (Section 6) and vaccines (section 7) and how these technologies can be used effectively for integrated control.
tKock, R.; Croft, S.; Dixon, M.; Fletcher, C.; Good, L.; Guzman, J.; Heymann, D.; Liyanage, R.; McKeever, D.; McNerney, R.; Peeling, R.; Moran, M.; Pfeiffer, D.; Waage, J.; Wu, L. DFID Zoonoses Report 6. Prioritising the need for new diagnostics, medicine, vaccines and management practices of zoonoses which have significant impact in the developing world. Royal Veterinary College, Hatfield, UK (2012) 126 pp.