Comparison of four immunoassays to measure serum ferritin concentrations and iron deficiency prevalence among non-pregnant Cambodian women and Congolese children

Global standardisation of ferritin assays is lacking, which has implications for measurement and comparability

Abstract

Global standardisation of ferritin assays is lacking, which could have direct implications on the accurate measurement and comparability of ferritin concentration and iron deficiency prevalence rates in at-risk populations.

The authors measured serum ferritin concentrations using 4 immunoassays: the s-ELISA and the AxSYM™ analyzer were compared among 420 non-pregnant Cambodian women; the Centaur® XP analyzer, s-ELISA, and AxSYM™ analyzer were compared among a subset of 100 Cambodian women; and the s-ELISA and the Elecsys® 2010 analyzer were compared among 226 Congolese children aged 6–59 months.

This work is an output of the HarvestPlus Programme. The Department for International Development is one of the main donors for HarvestPlus.

Citation

Karakochuk, Crystal D., Kyly C. Whitfield, Aviva I. Rappaport, Susan I. Barr, Suzanne M. Vercauteren, Judy McLean, Kroeun Hou, Aminuzzaman Talukder, Lisa A. Houghton, Karl B. Bailey, Erick Boy, and Timothy J. Green. 2017. Comparison of four immunoassays to measure serum ferritin concentrations and iron deficiency prevalence among non-pregnant Cambodian women and Congolese children. Clinical Chemistry and Laboratory Medicine55 (1): 65-72. https://doi.org/10.1515/cclm-2016-0421.

Comparison of four immunoassays to measure serum ferritin concentrations and iron deficiency prevalence among non-pregnant Cambodian women and Congolese children

Published 1 January 2017