Colorimetric Phage-Based Assay for Detection of Rifampicin Resistant Mycobacterium tuberculosis.

From:
Department for International Development
Published
1 January 2007
Document Type:
Journal Article
Theme:
Health
Authors:
McNerney, R., Mallard, K., Lemma, E., Donoghue, H.D., Urassa, H.M.R.

Abstract

Tests based on bacteriophage replication enable rapid screening of Mycobacterium tuberculosis for drug resistance. We describe a novel broth-based colorimetric method for detecting phage replication. When clinical isolates were tested by this novel method, high concordance was observed with both the traditional phage assay and gene mutation analysis for detection of resistance to rifampin.

Citation

Journal of Clinical Microbiology (2007) 45 (4) 1330-1332 [doi: 10.1128/JCM.02028-06]

Published 1 January 2007
Contents