Cassava is an important staple food crop in Africa and South America; however, ubiquitous deleterious mutations may severely decrease its fitness. To evaluate these deleterious mutations, the authors constructed a cassava haplotype map through deep sequencing 241 diverse accessions and identified more than 28 million segregating variants.
This work is part of the “Next Generation Cassava Breeding Project” which is supported by the UK Department for International Development, in partnership with the Bill & Melinda Gates Foundation.
Ramu, P., W. Esuma, R. Kawuki, I.Y. Rabbi, C. Egesi, J. V Bredeson, R.S. Bart, J. Verma, E.S. Buckler, and F. Lu. Cassava haplotype map highlights fixation of deleterious mutations during clonal propagation. Nature Genetics; https://doi.org/10.1038/ng.3845
Cassava haplotype map highlights fixation of deleterious mutations during clonal propagation