The experience of the ARROW trial highlights the importance of dialogue and communication between researchers and ethics bodies to ensure that children participate in research that will contribute to an improvement in their care while their safety and rights are protected. The Zimbabwean researchers’ relationship with caregivers was strengthened when those who were guardians of orphaned children were given permission to act as \"legally authorized representatives\" and provide informed consent for their participation in ARROW. Forty percent (40%) of the children enrolled in ARROW in Zimbabwe have lost one or both parents and live with relatives. Engagement of care-givers who are part of the community has the potential to pave the way for translation of the ARROW research findings into practice.
Evidence For Action Case Study No. 06 July 2010, 2 pp.