Burden and determinants of bacterial vaginosis in HIV uninfected women aged 18 years and over, enrolled in the MDP301 clinical trial in the Umkhanyakude district of northern KwaZulu Natal.
Background: Bacterial vaginosis (BV) results from a combination of factors, including a shift from the predominant Lactobacillus species to a polymicrobial flora. The sequelae of BV include pelvic inflammatory discharge (PID), urinary tract infections, vaginal discomfort, endometritis, preterm labour, and septicaemia. BV also predisposes women to acquisition of sexually transmitted infections (STI), including HIV. Sexual practice, douching and use of the intrauterine contraceptive device are known to upset the normal balance of bacteria in the vagina and may be associated with BV, but other risk factors are not fully understood. This analysis seeks to assess determinants of BV in HIV negative women. Methodology: Baseline laboratory, sexual behaviour and demographic data from the first 600 women enrolled in the MDP301 vaginal microbicide trial were analysed in STATA. Vaginal slides were assessed for BV using the Ison and Hay BV scoring method (categorizing Grade III=positive; grade II= intermediate shift; grade 0, I and IV= negative BV). Logistic regression was used to determine baseline factors associated with BV. Results: Preliminary results showed a BV prevalence of 52% (95% C.I: 48.5-56.7). In univariate analysis, BV was significantly associated with: education – OR=0.64 (95% CI: 0.46-0.89); infection with Trichomonas vaginalis (TV) – chi<sup>2</sup> = 15.8, p
Poster from Microbicides 2008, New Delhi, India, 24-27 February 2008.