Tuberculosis is rising in the developing world due to poor health care, human immunodeficiency virus type 1 infection, and the low protective efficacy of the Mycobacterium bovis BCG vaccine. A new vaccination strategy that could protect adults in the developing world from tuberculosis could have a huge impact on public health. The auathors show that BCG boosted by poxviruses expressing antigen 85A induced unprecedented 100% protection of guinea pigs from high-dose aerosol challenge with Mycobacterium tuberculosis, suggesting a strategy for enhancing and prolonging the efficacy of BCG.
Williams, A.; Goonetilleke, N.P.; McShane, H.; Clark, S.O.; Hatch, G.; Gilbert, S.C.; Hill, A.V.S. Boosting with Poxviruses Enhances Mycobacterium bovis BCG Efficacy against Tuberculosis in Guinea Pigs. Infection and Immunity (2005) 73 (6) 3814-3816. [DOI: 10.1128/IAI.73.6.3814-3816.2005]