Bacteriology of ear discharge in HIV-infected children on ART in the ARROW trial in Uganda and Zimbabwe

Abstract

Otitis media (OM) is common in HIV-infected children, but there are few data on: common causative agents of OM; the antimicrobial sensitivity patterns; the variation with age among HIV-1 infected African children on antiretroviral therapy (ART). ARROW (Anti Retroviral Research for Watoto) is a randomised trial investigating first-line treatment and monitoring strategies in 1207 previously untreated HIV-1-infected children initiating ART; and children who presented with an ear discharge during follow-up had ear swabs taken to determine the causative organisms and sensitivity patterns using standard microbiological techniques. A total of 266 samples of pus discharge from ears were collected from 153 patients over a 3 year period. The results showed that the median age was 2.5 years, IQR 2.3-2.9; 52% males; and that 209 (79%) cultures were positive. The most commonly isolated organism was Pseudomonas aeruginosa. Ear infection rates in HIV-infected children decreased with age and increasing time on ART. Pseudomonas aeruginosa and Staphylococcus aureus were the most commonly isolated organisms. Most isolated organisms were resistant to cotrimoxazole.

Citation

Katuramu, R.; Mhute, T.; Cook, A.; Mugyenyi, P.; Musoke, P.; Nahirya-Ntege, P.; Bwakura-Dangarembizi, M.I; Spyer, M.; Okello, P.; Kyakuwa, N.; Chigonde, S.; Natukunda, E.; Kekitiinwa, A.; Gibb, D.M. Bacteriology of ear discharge in HIV-infected children on ART in the ARROW trial in Uganda and Zimbabwe. Presented at 3rd International Workshop on HIV Paediatrics, 15 – 16 July 2011 / 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention, 17 – 20 July 2011, Rome, Italy. (2011) 1 pp.

Bacteriology of ear discharge in HIV-infected children on ART in the ARROW trial in Uganda and Zimbabwe

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