Otitis media (OM) is common in HIV-infected children, but there are few data on: common causative agents of OM; the antimicrobial sensitivity patterns; the variation with age among HIV-1 infected African children on antiretroviral therapy (ART). ARROW (Anti Retroviral Research for Watoto) is a randomised trial investigating first-line treatment and monitoring strategies in 1207 previously untreated HIV-1-infected children initiating ART; and children who presented with an ear discharge during follow-up had ear swabs taken to determine the causative organisms and sensitivity patterns using standard microbiological techniques. A total of 266 samples of pus discharge from ears were collected from 153 patients over a 3 year period. The results showed that the median age was 2.5 years, IQR 2.3-2.9; 52% males; and that 209 (79%) cultures were positive. The most commonly isolated organism was Pseudomonas aeruginosa. Ear infection rates in HIV-infected children decreased with age and increasing time on ART. Pseudomonas aeruginosa and Staphylococcus aureus were the most commonly isolated organisms. Most isolated organisms were resistant to cotrimoxazole.
Katuramu, R.; Mhute, T.; Cook, A.; Mugyenyi, P.; Musoke, P.; Nahirya-Ntege, P.; Bwakura-Dangarembizi, M.I; Spyer, M.; Okello, P.; Kyakuwa, N.; Chigonde, S.; Natukunda, E.; Kekitiinwa, A.; Gibb, D.M. Bacteriology of ear discharge in HIV-infected children on ART in the ARROW trial in Uganda and Zimbabwe. Presented at 3rd International Workshop on HIV Paediatrics, 15 &#8211; 16 July 2011 / 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention, 17 &#8211; 20 July 2011, Rome, Italy. (2011) 1 pp.
Bacteriology of ear discharge in HIV-infected children on ART in the ARROW trial in Uganda and Zimbabwe