Are rotavirus vaccines effective in preventing diarrhoea? Evidence Update, Child Health Series, February 2004

Abstract

Rotavirus vaccines tested to date prevent diarrhoea caused by rotavirus. However, one form of the vaccine has been associated with a rare life-threatening adverse event in post-marketing surveillance data. With a lack of data on mortality and questions over safety, this has precluded their use in routine clinical practice. Large randomised controlled trials, conducted in high, middle and low-income countries to determine the effect on mortality, and safety of the vaccines are needed. The trials should specify death, severe diarrhoea, intussusception and other adverse events as the main outcomes.

This evidence update was adapted from Soares-Weiser K, Goldberg E, Tamimi G, Pitan OC, Leibovici L. Rotavirus vaccine for preventing diarrhoea (Cochrane Review). In: The Cochrane Library, Issue 1, 2004.

Citation

Evidence Update, Child Health Series Effective Healthcare Alliance Programme, Liverpool School of Tropical Medicine 2pp.

Are rotavirus vaccines effective in preventing diarrhoea? Evidence Update, Child Health Series, February 2004

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