Increased efforts in antimalarial drug discovery are urgently needed.
The goal must be to develop safe and affordable new drugs to counter the
spread of malaria parasites that are resistant to existing agents. Drug
efficacy, pharmacology and toxicity are important parameters in the
selection of compounds for development, yet little attempt has been made
to review and standardize antimalarial drug-efficacy screens. Here, we
suggest different in vitro and in vivo screens for antimalarial drug
discovery and recommend a streamlined process for evaluating new
compounds on the path from drug discovery to development.
Fidock, D.A.; Rosenthal, P.J.; Croft, S.L.; Brun, R.; Nwaka, S. Antimalarial drug discovery: efficacy models for compound screening. Nature Reviews Drug Discovery (2004) 3 (6) 509-520. [DOI: 10.1038/nrd1416]
Antimalarial drug discovery: efficacy models for compound screening.