Age-specific mortality patterns in HIV-infected individuals: a comparative analysis of African community study data.
Abstract
Objectives: Description of age-specific mortality patterns of HIV-infected adults in African communities before introduction of HAART. Methods: Mortality data (deaths and person-years observed) for HIV-positive subjects aged 15-65 from six African community studies in five different countries were pooled, combining information from 1793 seroconverters and 8534 subjects who were HIV positive when first tested. Age-specific mortality hazards were modelled using parametric regression based on the Weibull distribution, to investigate effects of sex, and site-specific measures of mean age at incidence, crude mortality rate of uninfected people, and measures of epidemic maturity. Results: The combined studies yielded a total of 31 777 person-years of observation for HIV-positive subjects, during which time 2602 deaths were recorded. Mortality rates rose almost linearly with age, from below 50/1000 at ages
Citation
AIDS (2007) 21 (Suppl. 6) S87-S96 [doi:10.1097/01.aids.0000299415.67646.26]