A gene encoding a putative pyruvate decarboxylase (EC 22.214.171.124) was isolated from a genomic library of the filamentous fungus Aspergillus parasiticus strain SU-1. The deduced amino acid sequence showed 37% homology to PDC1 from Saccharomyces cerevisiae. Although A. parasiticus has an obligate growth requirement for oxygen, it produced ethanol in shake flask cultures indicating a response to anoxic conditions mediated by pyruvate decarboxylase.
FEMS Microbiology Letters (1994) 117 (2) 207-210 [DOI: 10.1111/j.1574-6968.1994.tb06766.x]
A pyruvate decarboxylase gene from Aspergillus parasiticus