The month-long scheme includes three sites: at the southbound entry slip road at junction 15, south of this entry slip road and at the Staffordshire services on the M6.
The southbound entry slip road will be closed for seven nights from 8.30pm to 6am, Monday to Friday, and 8pm to 6am at weekends.
There will be lane one and hard shoulder closures, and lane three in both directions will be closed south of the entry slip road for five days. The hard shoulder will be closed and there will be narrowed lanes at the entrance to the Staffordshire services for three days during the scheme.
The work involves extending the length of the southbound entry slip road at junction 15, and reducing it to one lane. Also, new warning signs will be installed at the entrance to the services.
The hard shoulder on the southbound section, and lane three in both directions, will be closed around one third of a mile south of the junction for five days from 18 March. This work will take place continuously for up to five days.
Three running lanes, with a speed restriction of 50mph, will be maintained at all times by use of the hard shoulder as a running lane.
When the southbound entry slip road is closed at junction 15, traffic will be diverted via the A500 and A34. This closure will be for seven consecutive nights from 10 March.
Highways Agency project manager Charlotte Foster said:
This scheme is designed to reduce the numbers of collisions on the M6 in this area, by improving both road safety and driver behaviour.
Most of the work will be carried out overnight with little impact on the public, but three running lanes will be kept during daytime work in the central reservation.
Members of the public should contact the Highways Agency Information Line on 0300 123 5000
Journalists should contact the Highways Agency press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer