The scheme will see pavement repairs and the installation of tactile paving at pedestrian crossing points on the Wolfshead Roundabout near Nesscliffe and resurfacing both carriageways between Montford Bridge and the Felton Butler roundabout.
The A5 will be closed in both directions from 8pm to 6am between the Wolfshead Roundabout and the A458 for two weeks and between Montford Bridge and the Felton Butler Roundabout for three weeks.
Traffic will be diverted via the A458 and A483 or vice versa.
Members of the public should contact the Highways Agency Information Line on 0300 123 5000
Journalists should contact the Highways Agency press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer