Work will be carried out over overnight, Monday to Sunday, for two weeks and will require full closures of the A46 between its junctions with the M40 junction 15 and the A452.
Work takes place from 10pm to 6am each night.
Highways Agency project manager Richard Gulliver said:
Improving the road surface will lead to a safer, smoother ride for road users and reduce the occurrence of potholes.
The work will be carried out at night to minimise disruption but we advise road users to allow extra time for their journeys.
During the closures traffic will be diverted from M40 junction 15 along the A429, A445 and A452, or vice versa. A separate signed diversion will be in place for HGVs.
Members of the public should contact the Highways Agency Information Line on 0300 123 5000
Journalists should contact the Highways Agency press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer