National Vaccine Evaluation Consortium

The National Vaccine Evaluation Consortium (NVEC) advises the Department of Health on the UK national immunisation schedule.

Role

The National Vaccine Evaluation Consortium (NVEC):

  • evaluates new vaccines and vaccination schedules to inform decisions about vaccinations given by the NHS
  • provides this information to the Department of Health using data from clinical trials in adults, children and babies
  • assists the Department of Health in developing the UK national immunisation schedule

In partnership with universities and NHS researchers, NVEC members are experts in their field: doctors, laboratory scientists, epidemiologists, nurses, statisticians and data managers. Some partners are involved in all studies, some in particular pieces of work only.

NVEC coordinates most of its clinical trials at Public Health England (PHE) through the Immunisation, Hepatitis and Blood Safety Health Protection Service. The trials take place at PHE clinical hubs in Gloucestershire and Hertfordshire.

Governance

Before a trial can start, the following must take place:

  1. A review of the ethics of the research coordinated by the National Research Ethics Service.
  2. Approval to use medicines, including vaccines, by the Medicines and Healthcare Products Regulatory Agency (MHRA).
  3. A review by the NHS Health Research Authority.

These governance processes ensure that:

  • patient safety has priority
  • trials are conducted properly
  • staff have the appropriate training and experience

Current clinical trials

NVEC trials assess the likely effect on people of a new vaccine when it is introduced.

Find out more about clinical trials on NHS Choices.

Flushed

We are looking at the nasal flu vaccine, which is being used by the Department of Health for children in the UK this autumn and winter (2017 to 2018).

We are inviting children who attend participating GPs in Gloucestershire and Hertfordshire, and St Mary’s hospital in London to join the study, see information leaflets for parents and children.

Information leaflet for children aged 6 to 13 years: flushed (PDF, 204KB, 2 pages)

Information leaflet for parents and carers: flushed (PDF, 312KB, 11 pages)

Past clinical trials

PRIME follow up

We are inviting previous participants in one of our studies of meningitis vaccination to come back and help us understand how immunity changes over time. This is happening in Hertfordshire and Gloucestershire.

PRIME follow up information leaflet (PDF, 160KB, 4 pages)

HPV follow up

We are inviting previous participants in one of our studies of HPV vaccination to come back and help us understand how immunity changes over time. This is happening in Hertfordshire and Gloucestershire. You can read the information leaflets at the links below:

HPV follow up information leaflet (PDF, 159KB, 4 pages)

Find out about the HPV follow up.

Multiboost

We are looking at 2 different vaccines currently licensed by the Department of Health for use with teenagers. This study is enrolling people in parts of Hertfordshire and NW London.

Information leaflet for participants aged 16 and above: Multiboost study (PDF, 293KB, 8 pages)

Information leaflet for participants aged under 16: Multiboost study (PDF, 145KB, 2 pages)

Parents and guardians information leaflet for those under 16: Multiboost study (PDF, 274KB, 8 pages)

Find out about Multiboost vaccine trial.

Sched3

We are assessing how the schedule would work if the number of pneumococcal vaccines given in infancy was reduced. This is being done in partnership with the Oxford Vaccine Group.

Parent information leaflet (PDF, 333KB, 7 pages)

Hepatitis B vaccination in infants (Infanrix)

This study offers infants a 6-in-1 vaccine (Infanrix-Hexa) that helps protect against hepatitis B, together with the other routine vaccinations in the UK infant immunisation schedule, and assesses their immune responses to the different vaccine.

Find out about the hepatitis B vaccination in infants (Infanrix).

iMAP2

In this study, NVEC is looking at the whooping cough vaccination given to expectant mothers and their babies. We hope to include a number of women who have not previously been vaccinated to see what happens when the vaccine is not given in pregnancy.

Find out about iMAP2.

Pneumococci in the nose (PIN)

We are assessing the bacteria that are found in the noses of children and people they live with to see how some of the vaccines included in the national schedule are working.

Participant information leaflet (PDF, 394KB, 4 pages)

Information leaflet for under 5 year olds (PDF, 297KB, 1 page)

Information leaflet for 5-10 year olds (PDF, 380KB, 1 page)

Information leaflet for 11-16 year olds (PDF, 360KB, 2 pages)

Information leaflet for 16-18 year olds (PDF, 398KB, 4 pages)

LAIV immuno

We are assessing how the nasal flu vaccine included in the national schedule is working when given to children each year, some of whom received the pandemic flu vaccine in 2009.

Parent information leaflet (PDF, 204KB, 8 pages)

Information leaflet for 5-6 year olds (PDF, 314KB, 1 page)

Information leaflet for 7-10 year olds (PDF, 159KB, 1 page)

For more information about past clinical trials, see The National Archives.

How to participate

To register to take part in a particular clinical trial, please email or text us your contact details, and the name of the trial you are interested in, to clinical.trials@phe.gov.uk or 0777 827 1328.

Contact details

clinical.trials@phe.gov.uk