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While an urgent EU-wide review of new information on liver safety is under way, promptly review patients on treatment. Only initiate daclizumab in restricted groups of patients with limited treatment options and keep all patients under close liver function monitoring.
Temporary safety measures are in place while an EU review investigates the link between cases of serious liver injury, including 4 cases requiring liver transplantation, and Esmya for uterine fibroids.…
Liver function tests should be carried out at treatment initiation, during treatment, and also when the dose is increased.
…Before initiation, discuss with women the rare risk of liver damage and advise them to seek urgent medical attention if they develop any symptoms or signs of liver injury.…
Serious liver injury has been reported during treatment with pirfenidone in the first year after initiation, including 2 cases with a fatal outcome.…
Advice and guidance on the health needs of migrant patients for healthcare practitioners.
…Serious liver injury has been reported on treatment with tocilizumab from 2 weeks to more than 5 years after initiation.
Volume 47 of the non-technical summaries granted under the Animals (Scientific Procedures) Act 1986 during 2013.
The epidemiology, symptoms, diagnosis and management of Andes hantavirus infection.
Cases of serious liver injury with elevated transaminases and bilirubin have been reported during treatment with Kaftrio–Kalydeco combination therapy.…
Check the VAT rules for food processing and abattoir services.
…Regular monitoring of cardiac, liver, and renal function during treatment is recommended
The indication of ulipristal acetate 5mg for uterine fibroids has been further restricted due to the risk of serious liver injury and liver failure, with some cases requiring liver transplantation.…
Liver function should be tested before and during treatment with temozolomide.
…Discuss with patients the risk of hepatic injury and the liver monitoring requirements before starting or continuing daclizumab and ask them to sign an acknowledgement form to confirm they understand the information.
New recommendations following a recent clinical trial which found that in patients with type 1 hepatorenal syndrome terlipressin may cause serious or fatal respiratory failure at a frequency higher than previously known, and…
Information for GPs about the NHS England and Public Health England initiative to support finding and treating diagnosed patients.
The European Medicines Agency (EMA) has recommended the immediate suspension of the marketing authorisation and recall of daclizumab (Zinbryta) in the EU following reports of serious inflammatory brain disorders, including e…
New simplified guidance on treating paracetamol overdose with intravenous acetylcysteine including an updated treatment nomogram.
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