Official Statistics

National norovirus and rotavirus report, week 42 report: data up to week 40 (8 October 2023)

Updated 11 April 2024

Applies to England

This monthly report covers the 2-week period between 25 September to 8 October 2023. Data reported here provide a summary of norovirus and rotavirus activity (including enteric virus (EV) outbreaks) in England up to reporting week 40 of the 2023/2024 season.

In this report the ‘5-season average’ is calculated from the same period during the 5 seasons of 2015/2016, 2016/2017, 2017/2018, 2018/2019 and 2022/2023. Refer to the data sources and reporting caveats sections for more information and for guidance on interpretation of trends.

The main messages of this report are:

1. Norovirus laboratory reports decreased in recent weeks and during the 2-week period of the 2023/2024 season (weeks 39 and 40) were 23% lower than the 5-season average of the same period.
2. Rotavirus activity also decreased in recent weeks, laboratory reports of rotavirus were 17% lower than the 5-season average during weeks 39 and 40.
3. Overall, the total number of reported EV outbreaks reported during weeks 39 and 40 remained lower than the 5-season average for the same 2-week period.
4. In recent weeks the number of norovirus outbreaks reported to Hospital Norovirus Outbreak Reporting System (HNORS) was lower than the 5-season average.

Background

No single surveillance system fully captures national changes in norovirus or rotavirus activity; therefore, this report presents data from 4 systems which collectively describe recent trends. Data is reported by season rather than calendar year, in order to capture the winter peak of activity in one reporting period. Refer to the data sources and reporting caveats sections for more information and for guidance on interpretation of trends.

Norovirus activity and the timing of the peak in reporting can vary considerably and differ from 1 season to the next. Transmission is mostly via contact with an infected person, but norovirus can also be spread by consumption of food contaminated with the virus or contact with contaminated surfaces. Norovirus transmission is influenced by many factors including, but not limited to, whether the person has been infected with norovirus recently, community contact patterns and the time of the year, as infections peak in the colder months and therefore norovirus is most prevalent during winter.

Since the 2019/2020 season norovirus activity in England has been more variable compared to historical trends, likely due to multiple impacts of the COVID-19 pandemic. Refer to the data sources and reporting caveats sections for more information on the impact of the pandemic. Throughout the 2019/2020 and 2020/21 seasons a reduction in reporting to national surveillance was observed, followed by unusual activity in the 2021/2022 season such as a greater proportion of outbreaks reported in educational settings than prior to the pandemic. In the 2022/2023 season norovirus activity returned to pre-pandemic levels and in early 2023 norovirus reporting peaked at a level twice as high as that experienced in the decade prior to the emergence of COVID-19.

Following the introduction of the rotavirus vaccine in July 2013 the total number of laboratory-confirmed rotavirus infections each season has remained low compared to the pre-vaccine period. A 77% decrease in laboratory-confirmed rotavirus infections in infants was observed in the first season following vaccine introduction (1).

UKHSA routinely undertakes norovirus characterisation as part of national surveillance to monitor the diversity of circulating strains. This molecular surveillance enables detection of novel strains or emergence of existing strains that could lead to a strain replacement event and which have previously been associated with a temporal shift in norovirus activity (2). Norovirus activity varies from season to season and therefore differences will be observed between every season.

Worldwide the most commonly detected norovirus genotype is genogroup II- genotype 4 (GII.4). Historically between 1995 and 2013 there have been 5 global GII.4 strain replacements events (3, 4). Since the winter of the 2012/2013 season and prior to the emergence of COVID-19 in England the most frequently detected strain was Norovirus/GII.4/Sydney/2012 or GII.4 Sydney2012-like variants (5).

To enable effective molecular surveillance, it is crucial that samples are obtained from suspected norovirus cases or outbreaks for laboratory confirmation and then norovirus-positive samples are referred on to the Enteric Virus Unit (EVU) for characterisation.

Laboratory surveillance

Data presented here is derived from the Second-Generation Surveillance System (SGSS). Refer to the data sources and reporting caveats sections for more information and for guidance on interpretation of trends.

So far up to week 40 of the 2023/2024 season the cumulative number of positive norovirus laboratory reports in England (992 laboratory reports) was 35% higher than the 5-season average for the same period (734 laboratory reports).

Norovirus activity over the 2-week period of weeks 39 and 40, 2023 (101 laboratory reports) was 23% lower than the 5-season average (131 laboratory reports) for the same 2-week period. The number of norovirus reports also decreased by 17% compared with activity during weeks 37 and 38, 2023 (122 laboratory reports, Figure 1).

Figure 1. Norovirus laboratory reports in England by week during the 2023/2024 season, compared to 5-season average

The cumulative number of positive rotavirus laboratory reports in England up to week 40 of the current season (704 laboratory reports) was 33% higher than the 5-season average for the same period (531 laboratory reports) (Figure 2).

Rotavirus activity has decreased in recent weeks but during the 2-week period of weeks 39 and 40, 2023 (51 laboratory reports) and was 17% lower than the 5-season average (61 laboratory reports) for the same period.

Figure 2. Rotavirus laboratory reports in England by week during the 2023/2024 seasons, compared to 5-season average

Outbreak surveillance

Data presented here is derived from HPZone and the HNORS. Refer to the data sources and reporting caveats sections for more information and for guidance on interpretation of trends.

Overall up to week 40 of the 2023/2024 season the cumulative number of EV gastroenteritis outbreaks reported to HPZone was 26% lower than the 5-season average, 460 and 619 outbreaks respectively (Figure 3).

In weeks 39 and 40 the total number of reported EV outbreaks remained lower than the 5-season average for the same 2-week period (35% lower, 82 versus 126 respectively).

During the 2-week period of weeks 39 and 40, 2023 the majority of reported EV outbreaks (all suspected or confirmed as norovirus) occurred in educational settings (49%, Figure 3), returning to levels  comparable to that seen during the 2- weeks of weeks 39 and 40 in the 5 seasons from which the 5-season average was calculated.

During the 5 seasons from which the 5-season average was calculated, overall, 63% of all reported outbreaks attributed to EVs (norovirus, rotavirus, sapovirus and astrovirus), occurred in care home settings, 20% in educational settings, 11% in hospital settings and 6% in ‘other’ settings. Of the outbreaks attributed to EVs, 99% were reported as suspected and confirmed norovirus outbreaks. Only 14% of reported EV outbreaks were laboratory confirmed as norovirus during the previous 5 seasons.

Figure 3. Enteric virus gastroenteritis outbreaks reported to HPZone in England by setting during the 2023/2024 season, compared to 5-season average

Up to week 40 of the 2023/2024 season 12 outbreaks have been reported to HNORS (Figure 4), 54% lower than the same as the 5-season average for the same period (26 outbreaks). Overall 92% of outbreaks were laboratory confirmed as norovirus.

During the 5 seasons from which the 5-season average was calculated, overall, 80% of outbreaks reported to HNORS were laboratory confirmed as norovirus.

Figure 4. Suspected and confirmed norovirus outbreaks reported to HNORS in England by week of occurrence during the 2023/2024 seasons compared to the 5-season average

Molecular surveillance for norovirus

Data presented here provided by UKHSA’s Enteric Virus Unit (EVU) and is used by UKHSA to monitor circulating norovirus variants. Refer to the data sources and reporting caveats sections for more information and for guidance on interpretation of trends.

Of the 96 norovirus positive samples characterised during the 2023/ 2024 season to date, 68% (65 out of 96) were genogroup 2 (GII); 31% (30 out of 96) were genogroup 1 (GI) and 1% were mixed (1 out of 96). The most frequent norovirus GII genotype identified was GII.4 (17%) and the most frequently identified norovirus GI genotype was GI.6 and GI.3 (14%). The most commonly identified GII.4 norovirus strain so far this season is Norovirus/GII.4/Sydney/2012-like variants.

Due to low numbers of samples submitted for molecular surveillance in the early part of the season this data should be interpreted with caution.

Data sources

1. The Second-Generation Surveillance System (SGSS) is the national laboratory reporting system, recording positive laboratory reports of norovirus and rotavirus.
2. The Hospital Norovirus Outbreak Reporting System (HNORS) is a web-based scheme for reporting suspected and confirmed norovirus outbreaks in Acute NHS Trust hospitals, and captures information on the disruptive impact these outbreaks have in hospital settings.
3. HPZone is a web-based case and outbreak management system used by Health Protection Teams (HPTs) to record outbreaks they are notified of and investigate. In England, suspected and confirmed EV outbreaks (norovirus, rotavirus, astrovirus and sapovirus) are reported as ‘Gastroenteritis’ outbreaks. Please note this was not available for this time period.
4. Norovirus characterisation data is produced by the EVU and is used to monitor the diversity of circulating strains of norovirus in England.

Reporting caveats

Interpretation of trends

In order to capture the winter peak of activity in the reporting period the norovirus and rotavirus season runs from week 27 in year 1 to week 26 in year 2, that is, week 27 2023 to week 26 2024, July to June. The 2023/2024 season is compared to the 5-season average calculated from the 5-season period of 2015/2016 to 2018/2019 and 2022/2023. The 2019/2020, 2020/2021 and 2021/22 seasons are not included in this calculation due to the adverse impact of the emergence of COVID-19 on surveillance part way through the 2019/2020 season and the continued impact into the 2020/2021 and 2021/2022 seasons. In years with a week 53 (2015 and 2020) data is combined with week 52 data to avoid distortion of the figure.

Under-ascertainment is a recognised challenge in enteric virus surveillance with sampling, testing and reporting criteria known to vary by region. In addition, samples for microbiological confirmation are collected in a small proportion of community outbreaks. Therefore, this report provides an overview of enteric virus activity across England and data should be interpreted with caution.

All surveillance data included in this report is extracted from live reporting systems, is subject to a reporting delay, and the number reported in the most recent weeks may rise further as more reports are received. Therefore, data pertaining to the most recent 2 weeks is not included.

Impact of COVID-19 pandemic on surveillance

The UK Health Security Agency (UKHSA) relaunched the Official Statistics National Norovirus and Rotavirus Report after it was temporarily suspended due to quality issues with the data from the 4 aforementioned data sources during the COVID-19 pandemic period. Additional analyses of this data were undertaken and demonstrated the quality of this data was comparable with the data collected before the pandemic and therefore reporting was allowed to resume as an Official Statistic. Between December 2020 and October 2022 the report was replaced by the National Norovirus and Rotavirus Bulletin to ensure an overview of norovirus and rotavirus activity in England continued to be available to the public (data covering the periods 2020/2021 and 2021/2022 is available at National norovirus and rotavirus bulletins 2020 to 2021: management information and National norovirus and rotavirus bulletins 2021 to 2022: management information ).

The COVID-19 pandemic impacted activity across many gastrointestinal pathogen surveillance indicators for England in 2020 and 2021, and reduced norovirus reporting continued into early 2022. The reasons for the reduction in norovirus reporting are considered to be multifactorial. It is likely that the interventions implemented to control COVID-19 led to a reduction in enteric virus transmission. However, when considering the surveillance data reported here, the magnitude of the reduction is unlikely to be wholly attributable to these control measures alone. It is likely that other factors such as, but not limited to, changes in ascertainment, access to health care services and capacity for testing also contributed to the observed reduction due to changes in ascertainment and varied over time. The reduction in norovirus reporting to national surveillance during the 2019/2020 and 2020/2021 seasons also lead to a period of low referral of norovirus-positive samples for characterisation. Therefore, trends for the 2019/2020, 2020/2021 and 2021/2022 seasons should be interpreted with caution.

SGSS data

SGSS data is England only, week number is calculated from specimen date and location is based on laboratory geography. Norovirus data include faecal and lower Gastrointestinal tract specimen types only. Reporting may be subject to differences in regional ascertainment.

HPZone data

HPZone data utilises week of date of outbreak entry on to HPZone for analyses due to mandatory completion of the field. While this usually reflects the date of notification, batch reporting of outbreaks can occur.

HNORS data

HNORS reporting is voluntary and variations may reflect differences in ascertainment or reporting criteria by region. National guidance recommends closure of the smallest possible unit in hospitals. Therefore, not all outbreaks reported to HNORS result in whole ward closure (some closures are restricted to bays only) and not all suspected cases are tested. Additionally, not all suspected cases are tested for norovirus, often only a proportion of individuals will be tested in any suspected outbreak.

Week number is calculated from date of first case onset for HNORS data.

From May to October 2019 and during February 2020 the HNORS website was temporarily offline. The reliance on manual data collation during this period may have negatively impacted ascertainment so trends should be interpreted with caution.

Norovirus characterisation data

Norovirus genotype and GII.4 strain characterisation data from the reference laboratory are subject to a reporting delay, and the numbers reported in any week may rise further additional characterisation data become available.

References

1. Atchison and others. ‘Rapid declines in age group–specific rotavirus infection and acute gastroenteritis among vaccinated and unvaccinated individuals within 1 year of rotavirus vaccine introduction in England and Wales’ , The Journal of Infectious Diseases: volume 213, pages 243 to 249 (viewed on 17 October 2022)

2. Allen and others. ‘Emergence of the GII-4 norovirus Sydney2012 strain in England, winter 2012–2013’, The Public Library of Science One, volume 2, article: e88978 (viewed on 17 October 2022)

3. Allen and others. ‘Characterisation of a GII-4 norovirus variant-specific surface-exposed site involved in antibody binding’ Virology Journal, volume 6, article number: 150 (viewed on 17 October 2022)

4. Zakikhany and others. ‘Molecular evolution of GII-4 Norovirus strains’ The Public Library of Science One, volume 7, article: e41625 (viewed on 17 October 2022)

5. Ruis C and others. ‘The emerging GII.P16-GII.4 Sydney 2012 norovirus lineage is circulating worldwide, arose by late-2014 and contains polymerase changes that may increase virus transmission’ The Public Library of Science One, volume 6, article: e0179572 (viewed on 17 October 2022)

Further information

Further information about norovirus surveillance and rotavirus surveillance is available on GOV.UK.

Acknowledgements

We are grateful to all who provided data used in this report, including NHS Infection Control and Prevention staff (HNORS users), UKHSA local (HPTs) and UKHSA regional teams (Field Services) and UKHSA Regional Public Health and Collaborating Laboratories.

This report was produced by the Gastrointestinal Infections & Food Safety (One Health) Division, UKHSA.

Please direct any queries or comments to NoroOBK@ukhsa.gov.uk