Non-tech. summaries 2015: projects on the nervous system
Projects granted during 2015 with a primary purpose of basic research: nervous system.
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This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2015 with a primary purpose of basic research: nervous system.
The following projects were granted:
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brain plasticity with experience and recovery (plasticity, learning, stroke, exercise, experience)
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neuronal network activity underlying behaviour (brain, neuron, plasticity, cognition, neuromodulator)
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neural mechanisms in health and disease (neurophysiological function, neurophysiological dysfunction, ageing)
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circuit mechanisms governing network oscillations (septum, cortex, oscillations, theta, synapses)
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affect and cognition in rodents (affect, cognition, consumption, microstructure)
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role of neuroinflammation in depression and cognition (depression, inflammation, inflammasome)
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genetically modified rodent models of neurodegeneration (alzheimer’s; parkinson’s, motor neuron disease; transgenic rodents; novel therapeutics)
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delta-protocadherins in cortical development (cortex, development, delta-2 protocadherins, Pcdh19, EFMR)
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plasticity and function of the visual system (primary visual cortex; amblyopia; neurodevelopmental disorders; glaucoma)
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brain systems for rodent memory (brain, systems, rodent, memory)
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genetic and functional studies in neurodegenerative disease (neurodegeneration, alzheimer disease, down syndrome, motor neuron diseases, mouse)
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drug modification of opioid tolerance (opioid: tolerance: respiratory depression)
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novel imaging applied to the study of memory (learning, memory, imaging, synaptic plasticity, optics)
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bioenergetics of the nervous system (bioenergetics, mitochondria, inflammation, demyelination, neurodegeneration)
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support procedures for neuroscience studies (transgenic, behaviour, substances, tissue)
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neuropharmacology of vulnerability to compulsivity (addiction, compulsivity, vulnerability, neuropharmacology, rat)
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rodent models of neurodegenerative disease (huntington’s disease, cognition, locomotion, mice)
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spinal cord injury and repair (spinal cord; plasticity; regeneration; rehabilitation)
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mechanisms of myelination and synapse formation (epilepsy, neuropathy, genetic programme)
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blood vessels in cortical interneuron development (neocortex, interneurons, development, migration, blood vessels)
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neurophysiology of reward (brain1 neurons, reward, learning, decision making)
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investigating the neural basis of spatial and episodic memory (memory, episodic, alzheimer’s, hippocampus, behaviour)
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epigenetic regulation of neuronal development (brain, development, neurodegeneration, transcription)
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neuronal networks and pathways for communication (communication, neuroimaging, neurophysiology, primate, neuronal mechanisms)
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molecular pathogenesis of neurodegeneration (alzheimer’s O-GlcNAcylation neuropathology)
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neuronal and sensory functions of tmc genes (sensory transduction, taste, touch, hearing)
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mechanisms of perinatal brain injury (preterm, term, hypoxia-ischaemia, inflammation, translational)
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cognitive-enhancing properties of nicotine and related psychoactive substances (nicotine, attention, withdrawal, dependence)
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mechanism of brain function and malfunction (cognition, cell assemblies, EEG, dementia, transgenes)
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neuronal activity underlying sensory behaviour (brain, electrophysiology, imaging, information processing, somatosensory)
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GABAAR, neurosteroids and stress in brain function (GABA, neurotransmission, stress, depression, addiction)
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investigation of the in vivo action of G protein coupled receptors (neurodegeneration, physiology, drugs, cancer, diabetes)
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biological and psychological bases of addiction (drug abuse, transgenic mice, behaviour)
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characterisation of novel therapeutics (drug discovery)
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studying central nervous system repair (multiple sclerosis, cerebral palsy, central nervous system, repair, oligodendrocyte)
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studying myelinated axons in vivo using zebrafish (zebrafish, in vivo imaging, nervous system development)
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zebrafish models of movement disorders (parkinson’s disease, mitochondria, dopaminergic neurons, parkin, PINK1)
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post-operative cognitive decline: pathogenesis & protection (surgery; neuroinflammation; cognition; dementia; alzheimer’s)
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genetic analysis of axon guidance and maintenance (breeding, transgenic, neurodegeneration)
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analysis of fish development (eye, brain, stem cells, zebrafish)
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blood flow and tissue oxygenation in rodents (haemodynamic response, imaging, pre-clinical models)
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biological and psychological bases for addictions (drug abuse, transgenic mice, behaviour)
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molecular & cellular correlates of stress-induced behaviour (GABA, mental illness, noradrenaline, serotonin, emotion)
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neuronal circuitry of the spinal dorsal horn (pain, itch, spinal cord, interneuron, projection neuron)
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cellular functions of myosin motor proteins (cell function, neurodegeneration, transport)
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perioperative medicine related uses of anaesthetics (rodent; anaesthetics, noble gas; brain injury; cancer)
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cerebrovascular changes in the aged and diseased brain (ageing, alzheimer’s disease, blood vessel)
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synaptic plasticity in normal learning and addiction (memory, hippocampus, accumbens, opioid, heroin)
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misfolded protein and neurodegenerative disease (prion, amyloid, seeding, neurodegeneration, TSE)
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neuronal and glial AMPA and GABAA receptors in health and disease (synaptic transmission; neurons: neurological disease)
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studies to find improved treatments for movement disorders (parkinson’s disease dystonia neurodegeneration neuroprotection symptomatic treatment)
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neurovascular coupling in health ageing and disease (neurovascular coupling, dementia, ageing, epilepsy)
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animal models of neurodevelopmental disorders (rat, behaviour, pregnancy, gut, brain)
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antibodies to neuropeptidergic signalling molecules (antibody neuropeptide evolution echinoderm)
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basic mechanisms of chronic neurodegeneration (TSE, neurodegeneration, mouse models)
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connectivity and plasticity of developing and mature central nervous system circuits (brain development, neurons, synapses, axons)
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structural and functional plasticity in cortex (brain, plasticity, degeneration, synapses, learning)
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studying a human neurological disease-causing gene (epilepssy, motor neuron disease, autism)
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spinal sensory processing (somatosensory, dorsal root ganglion, spinal, analgesia)
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the role of neuropeptides in behaviour (vasopressin, oxytocin, social behaviours)
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memory in the rat (memory, learning)
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neural basis on spatial learning and memory (neural, spatial, learning, memory)
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the neural basis of spatial cognition and memory (rat, mouse, single neurons, behaviour, spatial memory, navigation)
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mechanisms contributing to analgesic use & misuse (opioid, GABA, neurotransmission, stress, nociception)
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functions of the murine trappc9 gene (brain development, stem cells, microcephaly)
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mechanism-based targets for new analgesics (analgesia, molecular targets, somatosensory, sensitisation)
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encoding behaviour from synapses to circuits (behaviour, neurons, communication, brain, experience)
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understanding successful brain repair in zebrafish (traumatic brain injury, tissue repair)
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ion channel function and epileptogenesis (ion channels, epilepsy, brain)
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neuroprotective treatments for traumatic injury (neuroprotection, spinal cord injury, regeneration, nerve injury, repair)
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repairing the damaged peripheral nerve (sciatic nerve, axon regeneration, neuroprotection, scarring, nerve conduits)
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cell-specific chromatin profiling in mouse cortex (cerebral cortex development; targeted DamID)
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the role of central sympathetic control neurones (cardiovascular control, paraventricular nucleus)
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the molecular and cellular mechanisms that underpin cns plasticity (stem cells, myelin, regeneration)
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recovery of peripheral nerve function (nerve, bladder, physiology)