Guidance

Carcinogenic dose response: defining points of departure and potency estimates

A statement from the Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COC).

From:
Public Health England
Published
29 September 2014
Last updated
16 December 2020 — See all updates

Documents

Defining a point of departure and potency estimates in carcinogenic dose response

Ref: COC/G 05 – Version 2 (2020)

PDF, 338 KB, 22 pages

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Details

This document describes:

  • how to derive points of departure (POD) such as the Benchmark Dose (BMD) and potency estimates, such as the T25 and TD50
  • how to use these measures to estimate the relative potency of carcinogens
Published 29 September 2014
Last updated 16 December 2020 + show all updates

  1. Added version 2 (2020).

  2. Updated with latest version of document.

  3. First published.

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