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The monitoring requirements and discontinuation criteria for dimethyl fumarate (Tecfidera) have been strengthened following a small number of reports of progressive multifocal leukoencephalopathy (PML) in patients with mild lymphopenia. Continue to monitor lymphocyte counts and advise patients to seek urgent...
Cases of progressive multifocal leukoencephalopathy have been reported in patients taking dimethyl fumarate for multiple sclerosis, who all had prolonged lymphopenia.
Check full blood counts before prescribing dimethyl fumarate and then every 6 to 12 months. Stop treatment immediately if you suspect progressive multifocal leukoencephalopathy.
A summary of letters and drug alerts recently sent to healthcare professionals.
In November, letters were sent regarding thalidomide, mycophenolate mofetil, nicorandil, InductOs, and dimethyl fumarate
Product Safety Report for TUMAKOU High Frequency Beauty Machine presenting a high risk of electric shock.
Product security factsheet accompanying the Product Security and Telecommunications Infrastructure Bill, outlining the problems the Bill will address and how.
An overview of the legal requirements for children’s medicines that Marketing Authorisation Holders (MAHs) need to abide by.
Review looking at the future of financial technologies up to 2025.
Check the tariff classification for articles made of cermet.
This series brings together all documents relating to Defra's Permanent Secretary’s meetings with external organisations
Understand the challenges and considerations around using GraphQL such as security, versioning, caching, tooling and team skills.
Details about our Private Finance team, our work and the history of private finance for social housing.
Exporters of groups of products of animal origin (POAO) to the EU and Northern Ireland can join the groupage export facilitation scheme (GEFS) to use 30-day support attestations.
The Medicines and Healthcare products Regulatory Agency (MHRA) responses to freedom of information (FOI) requests for week commencing 11 July 2022
Find out what’s involved and how to apply for funding to support the planting and establishment of standard trees in urban and peri-urban areas in England.
The New Alliance for Food Security and Nutrition - cooperation frameworks
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