Salmonella infections are a common bacterial cause of invasive disease in people with sickle cell disease especially children
Background: Salmonella infections are a common bacterial cause of invasive disease in people with sickle cell disease especially children, and are associated with high morbidity and mortality rates. Although available in some centres, people with sickle cell anaemia are not routinely immunized with salmonella vaccines. This is an update of a previously published Cochrane Review.
Objectives: To determine whether routine administration of salmonella vaccines to people with sickle cell disease reduces the morbidity and mortality associated with infection.
This research is supported by the Department for International Development’s Evidence Building and Synthesis Research Programme which is led by Liverpool School of Tropical Medicine
Odey, F.; Okomo, U.; Oyo-Ita, A. Vaccines for preventing invasive salmonella infections in people with sickle cell disease. Cochrane Database of Systematic Reviews (2015) http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006975.pub3/full