The leishmaniases are protozoal diseases that severely affect large populations in tropical and subtropical regions. There are only limited treatment options and preventative measures. Vaccines will be important for prevention, control and elimination of leishmaniasis, and could reduce the transmission and burden of disease in endemic populations. The authors report the development of a DNA vaccine against leishmaniasis that induced T cell–based immunity and is a candidate for clinical trials.
Shantanabha Das et al. (2014) Modular multiantigen T cell epitope–enriched DNA vaccine against human leishmaniasis . Science Translational Medicine 30 Apr 2014: Vol. 6, Issue 234, pp. 234ra56 DOI: 10.1126/scitranslmed.3008222
Modular multiantigen T cell epitope–enriched DNA vaccine against human leishmaniasis (subscription or purchase of article required)