Using amodiaquine and sulfadoxine-pyrimethamine together to treat uncomplicated malaria instead of sulfadoxine-pyrimethamine alone may reduce treatment failure; adding chloroquine to sulfadoxine-pyrimethamine may not be beneficial. Chloroquine, amodiaquine, and sulfadoxine-pyrimethamine are relatively inexpensive drugs to treat malaria. Treatment failure is a problem when these drugs are used alone because malaria parasites have become resistant to them. Based on evidence from randomized controlled trials, a combination of amodiaquine plus sulfadoxine-pyrimethamine may reduce treatment failure in some locations. It appears less likely that chloroquine plus sulfadoxine-pyrimethamine will have a treatment benefit over sulfadoxine-pyrimethamine alone.
The Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD000386. DOI: 10.1002/14651858.CD000386.pub2.