We review studies of the implementation of human papillomavirus (HPV) vaccination programmes in developed and developing countries. The review spans the period from establishment of long-term vaccine efficacy follow-up studies, operational research on issues of vaccine preparedness, and relevant predictive modelling studies during the pre-licensure phase to plans of phase IV effectiveness trials, forms of epidemiological surveillance, and further operational research in the post-licensure phase. Much of the research is already ongoing. Depending on the results of the planned immuno bridging studies among HIV-negative and HIV-positive women, further phase III and/or phase IV trials may be warranted.
Vaccine (2006) 24 (Suppl. 3) S233-41 [In: HPV Vaccines and Screening in the Prevention of Cervical Cancer, ed. by: Bosch, F.X.; Cuzick, J.; Schiller, J.Y.; Garnett, G.P.; Meheus, A.; Franco, E.L.; Wright, T.C.] [doi:10.1016/j.vaccine.2006.05.109]