- Department for International Development
- Document Type:
- Journal Article
- Sibanda, T., Nyirenda, S., Agizew, T.B., Bozeman, L., Castro, K.G. Davis, M.K., Kilmarx, P.H., Moeti, T.L., Moffat, H.J., Mosimaneotsile, B., Motsamai, O.I., Samandari, T., Shang, N., Talbot, E.A., Tedla, Z., and Wells, C.D.
Background: In accordance with WHO guidelines, people with HIV infection in Botswana receive daily isoniazid preventive therapy against tuberculosis without obtaining a tuberculin skin test, but duration of prophylaxis is restricted to 6 months. We aimed to assess effectiveness of extended isoniazid therapy.
Methods: In our randomised, double-blind, placebo-controlled trial we enrolled adults infected with HIV aged 18 years or older at government HIV-care clinics in Botswana. Exclusion criteria included current illness such as cough and an abnormal chest radiograph without antecedent tuberculosis or pneumonia. Eligible individuals were randomly allocated (1:1) to receive 6 months' open-label isoniazid followed by 30 months' masked placebo (control group) or 6 months' open-label isoniazid followed by 30 months' masked isoniazid (continued isoniazid group) on the basis of a computer-generated randomisation list with permuted blocks of ten at each clinic. Antiretroviral therapy was provided if participants had CD4-positive lymphocyte counts of fewer than 200 cells per μL. We used Cox regression analysis and the log-rank test to compare incident tuberculosis in the groups. Cox regression models were used to estimate the effect of antiretroviral therapy. The trial is registered at ClinicalTrials.gov, number NCT00164281.
Findings: Between Nov 26, 2004, and July 3, 2009, we recorded 34 (3·4%) cases of incident tuberculosis in 989 participants allocated to the control group and 20 (2·0%) in 1006 allocated to the continued isoniazid group (incidence 1·26% per year vs 0·72%; hazard ratio 0·57, 95% CI 0·33—0·99, p=0·047). Tuberculosis incidence in those individuals receiving placebo escalated approximately 200 days after completion of open-label isoniazid. Participants who were tuberculin skin test positive (ie, ≥5 mm induration) at enrolment received a substantial benefit from continued isoniazid treatment (0·26, 0·09—0·80, p=0·02), whereas participants who were tuberculin skin test-negative received no significant benefit (0·75, 0·38—1·46, p=0·40). By study completion, 946 (47%) of 1995 participants had initiated antiretroviral therapy. Tuberculosis incidence was reduced by 50% in those receiving 360 days of antiretroviral therapy compared with participants receiving no antiretroviral therapy (adjusted hazard ratio 0·50, 95% CI 0·26—0·97). Severe adverse events and death were much the same in the control and continued isoniazid groups.
Interpretation: In a tuberculosis-endemic setting, 36 months' isoniazid prophylaxis was more effective for prevention of tuberculosis than was 6-month prophylaxis in individuals with HIV infection, and chiefly benefited those who were tuberculin skin test positive.
Samandari, T.; Agizew, T.B.; Nyirenda, S.; Tedla, Z.; Sibanda, T.; Shang, N.; Mosimaneotsile, B.; Motsamai, O.I.; Bozeman, L.; Davis, M.K.; Talbot, E.A.; Moeti, T.L.; Moffat, H.J.; Kilmarx, P.H.; Castro, K.G.; Wells, C.D. 6-month versus 36-month isoniazid preventive treatment for tuberculosis in adults with HIV infection in Botswana: a randomised, double-blind, placebo-controlled trial. Lancet (2011) 377 (9777) 1588-1598. [DOI: 10.1016/S0140-6736(11)60204-3]
Document Type: Journal Article
Authors: Sibanda, T. Nyirenda, S. Agizew, T.B. Bozeman, L. Castro, K.G. Davis, M.K. Kilmarx, P.H. Moeti, T.L. Moffat, H.J. Mosimaneotsile, B. Motsamai, O.I. Samandari, T. Shang, N. Talbot, E.A. Tedla, Z. Wells, C.D.