{"analytics_identifier":null,"base_path":"/government/publications/glp-1-medicines-for-weight-loss-and-diabetes-what-you-need-to-know","content_id":"2c9b4641-74ac-43e6-bbd6-7b1a34c13bc9","description":"Guidance on the safe and effective use of GLP-1 medicines for weight loss and diabetes.","details":{"attachments":[{"attachment_type":"html","command_paper_number":"","hoc_paper_number":"","id":"9340829","isbn":"","title":"GLP-1 medicines for weight loss and diabetes: what you need to know","unique_reference":"","unnumbered_command_paper":false,"unnumbered_hoc_paper":false,"url":"/government/publications/glp-1-medicines-for-weight-loss-and-diabetes-what-you-need-to-know/glp-1-medicines-for-weight-loss-and-diabetes-what-you-need-to-know"}],"body":"<div class=\"govspeak\"><p>Glucagon-like peptide-1 receptor agonists (GLP-1s or GLP-1RAs) are medicines that help people feel fuller by mimicking a natural hormone released after eating. Some newer medicines, like Mounjaro, also act on a second hormone involved in appetite and blood sugar control. You may see them referred to in the media as “weight loss injections” or “skinny jabs” but not all of these medicines are authorised for weight loss.</p>\n</div>","change_history":[{"note":"Updated to reflect new information on Non-arteritic anterior ischemic optic neuropathy (NAION)","public_timestamp":"2026-02-05T13:31:40Z"},{"note":"Updated attachment with new documents 'MHRA urges public to avoid illegal online weight-loss medicines this New Year' AND 'DSU: GLP-1 receptor agonists and dual GLP-1/ GIP receptor agonists: strengthened warnings on acute pancreatitis, including necrotising and fatal cases'","public_timestamp":"2026-01-29T14:20:34Z"},{"note":"Updated attached guidance to add section 'Switching between GLP-1 medicines'","public_timestamp":"2025-08-20T12:29:23Z"},{"note":"Added guidelines on avoiding pregnancy, contraceptive use, side effects, surgery, and proper syringe disposal. 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