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Information about when you need to submit substantial amendments to a clinical trial including changes to the trial sponsor or legal representative, Investigational medicinal product certification and importation.
Check when packaging is classified as a finished plastic packaging component, and what is meant by substantial modifications, to find out if you must register for the tax.
Change your protocol, update your authorisation, report safety issues, submit safety updates and complete your end-of-trial study report.
You’re disabled under the Equality Act 2010 if you have a physical or mental impairment that has a 'substantial' and 'long-term' negative effect on your ability to do daily activities
How to enforce copyright when somebody uses your work without your permission.
Find out about terrorist threat levels, national measures against terrorism and how to report suspect activity
This study assesses the impact on crime of the Metropolitan Police’s Operation BLUNT 2, which ran from May 2008 to April 2011.
This tax information and impact note allows qualifying investors an exemption from Corporation Tax on qualifying disposals of substantial shareholdings.
A consultation considering possible reform of the substantial shareholdings exemption, with a view to increasing its simplicity, coherence and international competitiveness.
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